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Duplex ultrasound is used to evaluate blood flow, venous leak, signs of atherosclerosis, and scarring or calcification of erectile tissue. Injecting prostaglandin, a hormone-like stimulator produced in the body, induces erection. Ultrasound is then used to see vascular dilation and measure penile blood pressure. Measurements are compared to those taken when the penis is flaccid.
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Erectile tissue, which is contained within the corpora cavernosa above the urethra, two main arteries and several veins and nerves.
Erectile dysfunction may be a sign of undiagnosed or poorly managed diabetes. People with diabetes who don't keep their blood sugar levels under control can develop nerve damage (neuropathy). Often it's the nerves of the extremities, such as the hands and feet, that are damaged. But the genitals can be affected, too.
"This is the same as any other part of the body. It's what we in vascular surgery refer to as the 'use it or lose it' concept," said Dr. Hossein Sadeghi-Nejad, an associate professor of urology at UMDNJ New Jersey Medical School Hackensack University Medical Center. "Sexual activity will promote maintenance of normal erectile function down the line."
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One way to improve erectile dysfunction is to make some simple lifestyle changes. For some men, adopting a healthier lifestyle, such as quitting smoking, exercising regularly, and reducing stress, may be all that is needed to find relief. For those who require more intensive treatment, adopting these lifestyle changes in addition to other treatments can further help.
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"No in-vivo studies in an animal model have been performed at this regard, so a lot of work must be done. We would like to test in vivo [with animals] the molecule to understand if it really works in humans," said study lead author Mario Dell'Agli, of the University of Milan's laboratory of pharmacognosy. "At this stage of the research, we cannot say if the molecule we have synthesized possesses less side effects with respect to Viagra. However, this derivative seems to be in vitro [in lab tests] more selective than Viagra, because it targets [an enzyme involved in blood flow to the penis] more precisely."
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